Director Shareholding

GlaxoSmithKline PLC
23 July 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


20 July 2001   The Administrators of the SmithKline Beecham Employee Share 
               Ownership Trust ('the ESOT') notified the Company on the 23 July 
               2001, that 171,591 Ordinary Shares had been transferred from the 
               ESOT to participants of the SmithKline Beecham 1991 Share Option 
               Plan.


The company was informed of these transactions on 23 July 2001.

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


23 July 2001