Director Shareholding

GlaxoSmithKline PLC
9 October 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



5       The Administrators of the SmithKline Beecham Employee Share Ownership
October Trust ('the ESOT') notified the Company on the 9 October 2001, that
2001    220,606 Ordinary shares had been transferred from the ESOT to
        participants of the SmithKline Beecham 1991 Share Option Plan and 1,129
        Ordinary shares were purchased for participants of the SmithKline
        Beecham Bonus Investment Plan at a price of £18.88 per share.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


9 October 2001