Director Shareholding

GlaxoSmithKline PLC
19 September 2001



LETTER TO COMPANY ANNOUNCEMENTS OFFICE

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares 
of GlaxoSmithKline plc.

14 September 2001   The Administrators of the SmithKline Beecham Employee Share 
                    Ownership Trust ('the ESOT') notified the Company on the 18 
                    September 2001, that 35,209 Ordinary shares had been        
                    transferred from the ESOT to participants of the SmithKline 
                    Beecham 1991 Share Option Plan and that 1,746 Ordinary      
                    shares had been transferred from the ESOT to participants of
                    the SmithKline Beecham Bonus Investment Plan. The trust also
                    purchased 48 Ordinary shares at a price of £17.48 per share 
                    for participants of the SmithKline Beecham Unapproved Share 
                    Matching Plan.

The ESOT is a discretionary fund of which all employees or former employees of 
SmithKline Beecham plc and its subsidiaries are potential beneficiaries.  One of
the Company's directors, Dr J P Garnier is therefore, interested in the shares 
held in the fund from time to time in the same way as other employees or former 
employees of SmithKline Beecham plc and its subsidiaries.

S M Bicknell
Company Secretary

FROM GLAXOSMITHKLINE PLC