Director Shareholding

GlaxoSmithKline PLC 6 April 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 5 The Administrators of the SmithKline Beecham US Retirement Savings Plan April ('the Plan') notified GlaxoSmithKline plc on the 6 April 2001, that as a 2001 result of movement in the fund on the 5 April 2001, the number of Ordinary share ADRs held by the fund had decreased from 17,620,548 to 17,610,404 at an average price of $52.6000. The Plan is a discretionary fund of which all employees or former employees of SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One of the Company's directors, Dr J P Garnier is therefore, interested in the shares held in the fund from time to time in the same way as other employees or former employees of SmithKline Beecham plc and its subsidiaries. S M Bicknell Company Secretary 6 April 2001

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