Director Shareholding

GlaxoSmithKline PLC
16 August 2001



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

15      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
August  Trust ('the Trust'), transferred 32,189 Ordinary Shares in the Company
2001    to participants of the Glaxo Wellcome International Share Option Scheme
        and the Glaxo Wellcome 1999 Share Option Plan - Part 1.





The Company was advised of this transaction on 16 August 2001.




The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.






S M Bicknell

Company Secretary




16 August 2001