Director Shareholding

GlaxoSmithKline PLC
18 April 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


16    The Administrators of the SmithKline Beecham US Retirement Savings Plan
April ('the Plan') notified GlaxoSmithKline plc on the 17 April 2001, that as a
2001  result of movement in the fund on the 16 April 2001, the number of
      Ordinary share ADRs held by the fund had increased from 17,549,817 to
      17,592,744 at an average price of $52.3900.


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


18 April 2001