Director Shareholding

GlaxoSmithKline PLC
18 April 2001

                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


13    The Administrators of the SmithKline Beecham Employee Share Ownership
April Trust ('the ESOT') notified the Company on the 17 April 2001, that
2001  307,909 Ordinary shares had been transferred from the ESOT to
      participants of the SmithKline Beecham 1991 Share Option Plan and that
      1,129 Ordinary shares in the Company had been transferred by the ESOT to
      participants of the SmithKline Beecham Bonus Investment Plan. The ESOT
      also transferred 173,435 Ordinary shares in the Company to participants
      of the Mid-Term Incentive Plan.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


18 April 2001