Director Shareholding

GlaxoSmithKline PLC
6 June 2001



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

4      Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
June   Trust ('the Trust'), transferred 20,721 Ordinary Shares in the Company to
2001   participants of the Glaxo Wellcome UK Share Option Scheme and the Glaxo
       Wellcome International Share Option Scheme.





The Company was advised of these transactions on 5 June 2001.




The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.






S M Bicknell

Company Secretary




6 June 2001