Director Shareholding

GlaxoSmithKline PLC
14 March 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

12 March 2001   Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome 
                Employee Trust ('the Trust'), transferred 15,246 Ordinary Shares

                in the Company to participants of the Glaxo Wellcome 1999 Share 
                Option Plans Part 1 and 2, Glaxo Wellcome UK Share Option Scheme

                and the Glaxo Wellcome International Share Option Scheme. The 
                Trust also sold 25,028 Ordinary shares in the Company at a price

                of £18.66 per share and 16,883 Ordinary shares in the Company at

                a price of £18.45 per share.

The Company was advised of this transaction on 14 March 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary


14 March 2001