Director Shareholding

GlaxoSmithKline PLC
18 May 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

17 May 2001     Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome 
                Employee   Trust ('the Trust'), transferred 231,278 Ordinary 
                Shares in the Company to participants of the Glaxo Wellcome 
                International Share Option Scheme, Glaxo Wellcome 1999 Share 
                Option Plan and the Glaxo Wellcome UK Share Option Scheme.


The Company was advised of these transactions on 18 May 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe are therefore
interested in the shares held in the Trust from time to time in the same way
as other employees or former employees of Glaxo Wellcome plc and its
subsidiaries.


S M Bicknell

Company Secretary


18 May 2001