Director Shareholding

GlaxoSmithKline PLC
6 February 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


2nd      The Administrators of the SmithKline Beecham US Retirement Savings
February Plan ('the Plan') notified GlaxoSmithKline plc on the 5th February
2001     2001, that as a result of movement in the fund on the 2nd February
         2001, the number of Ordinary share ADRs held by the fund had increased
         from 17,585,711 to 17,621,139 at an average price of $53.0500.

The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary

6th February 2001