Director Shareholding

GlaxoSmithKline PLC
26 February 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

23 February 2001    Abacus (GW) Trustees Limited, as trustee of The Glaxo 
                    Wellcome Employee Trust ('the Trust'), transferred 5,131 
                    Ordinary Shares in the Company to participants of the Glaxo 
                    Wellcome International Share Option Scheme and the Glaxo 
                    Wellcome 1999 Share Option Plan. The Trust also sold 147,344

                    Ordinary Shares in the Company to participants of the Glaxo 
                    Wellcome Long Term Incentive Plan at a price of £19.30 per
                    share.

The Company was advised of this transaction on 26 February 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary


26 February 2001