Director Shareholding

GlaxoSmithKline PLC
26 February 2001



                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



22       The Administrators of the SmithKline Beecham US Retirement Savings
February Plan ('the Plan') notified GlaxoSmithKline plc on the 23 February
2001     2001, that as a result of movement in the fund on the 22 February
         2001, the number of Ordinary share ADRs held by the fund had decreased
         from 17,564,401 to 17,460,806 at an average price of $56.4900.


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


26 February 2001