Director Shareholding

GlaxoSmithKline PLC
1 May 2001

                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

27    The Administrators of the SmithKline Beecham Employee Share Ownership
April Trust ('the ESOT') notified the Company on the 1 May 2001, that 507,194
2001  Ordinary shares had been transferred from the ESOT to participants of the
      SmithKline Beecham 1991 Share Option Plan and that 5,746 Ordinary shares
      in the Company had been transferred by the ESOT to participants of the
      SmithKline Beecham Bonus Investment Plan

The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore, interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


1 May 2001