Director Shareholding

GlaxoSmithKline PLC
12 April 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



6      The Administrators of the SmithKline Beecham Employee Share Ownership
April  Trust ('the ESOT') notified the Company on the 9 April 2001, that 381,435
2001   Ordinary shares had been transferred from the ESOT to participants of the
       SmithKline Beecham 1991 Share Option Plan and that 1,054 Ordinary shares
       in the Company had been transferred by the ESOT to participants of the
       SmithKline Beecham Bonus Investment Plan. The ESOT also transferred
       302,006 Ordinary Shares in the Company from the Mid-Term Incentive Plan.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier is therefore interested in the
shares held in the fund from time to time in the same way as other employees
or former employees of SmithKline Beecham plc and its subsidiaries.






S M Bicknell

Company Secretary


12 April 2001