Director Shareholding

GlaxoSmithKline PLC 25 January 2001 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc. 24 January 2001 Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee Trust ('the Trust'), transferred 6,824 Ordinary Shares in the Company to participants of the Glaxo Wellcome International Share Option Scheme. The Company was advised of this transaction on 25 January 2001. The Trust is a discretionary trust of which all employees or former employees of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Sir Richard Sykes and John Coombe, as directors of Glaxo Wellcome plc, are therefore interested in the shares held in the Trust from time to time in the same way as other employees or former employees of Glaxo Wellcome plc and its subsidiaries. S M Bicknell Company Secretary 25 January 2001

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