Director Shareholding

GlaxoSmithKline PLC
14 February 2001


                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



9        The Administrators of the SmithKline Beecham Employee Share Ownership
February Trust ('the ESOT') notified the Company on the 13th February 2001,
2001     that on 9th February 2001, 122,353 Ordinary shares had been
         transferred from the ESOT to participants of the SmithKline Beecham
         1991 Share Option Plan and the SmithKline Beecham Bonus Investment
         Plan and also on that date 304 Ordinary shares in the Company had been
         purchased by the ESOT for participants of the SmithKline Beecham
         Unapproved Matching Plan at a price of £18.36 per share.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.


S M Bicknell

Company Secretary


14 February 2001