Director Shareholding

GlaxoSmithKline PLC
22 January 2001


                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.



19      The Administrators of the SmithKline Beecham Employee Share Ownership
January Trust ('the ESOT') notified the Company on the 19th January 2001, that
2001    8,634 Ordinary 25p shares had been transferred from the ESOT to
        participants of the SmithKline Beecham 1991 Share Option Plan and that
        1,345 Ordinary Shares in the Company had been purchased by the ESOT at
        a price of £17.98 per share.


The ESOT is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.



S M Bicknell

Company Secretary


22nd January 2001