Director Shareholding

GlaxoSmithKline PLC
6 March 2001



                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

5     Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
March Trust ('the Trust'), transferred 7,200 Ordinary Shares in the Company to
2001  participants of the Glaxo Wellcome International Share Option Scheme and
      20,658 Ordinary Shares in the Company to participants of the Glaxo
      Wellcome Long Term Incentive Plan. The Trust also sold 10,713 Ordinary
      shares in the Company at a price of £19.37 per share.


The Company was advised of this transaction on 6 March 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary

6 March 2001