Director Shareholding

GlaxoSmithKline PLC
9 January 2001



                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

28       The Administrators of the SmithKline Beecham US Retirement Savings
December Plan ('the Plan') notified GlaxoSmithKline plc on the 2nd January
2000     2001, that as a result of movement in the fund on the 28th December
         2000, the number of Ordinary share ADRs held by the fund had increased
         from 15,503,215 to 17,715,111 at an average price of $56.8125.

5       The Administrators of the SmithKline Beecham US Retirement Savings Plan
January ('the Plan') notified GlaxoSmithKline plc on the 8th January 2001, that
2001    as a result of movement in the fund on the 5th January 2001, the number
        of Ordinary share ADRs held by the fund had decreased from 17,715,111
        to 17,694,142 at an average price of $51.813.


The Plan is a discretionary fund of which all employees or former employees of
SmithKline Beecham plc and its subsidiaries are potential beneficiaries. One
of the Company's directors, Dr J P Garnier, as a director of SmithKline
Beecham plc, is therefore, interested in the shares held in the fund from time
to time in the same way as other employees or former employees of SmithKline
Beecham plc and its subsidiaries.




S M Bicknell

Company Secretary


9th January 2001