Director Shareholding

GlaxoSmithKline PLC
5 January 2001

         Directors' Interests in GlaxoSmithKline plc Ordinary Shares



I give below details of the directors' interests in the Ordinary Shares
('Shares') and American Depositary Shares (which represent two Shares)
('ADSs') of GlaxoSmithKline plc ('the Company') as of the commencement of
trading of the Company :
Name of director            Number of      Total holdings as a % of share Notes
                               Shares                               class

Sir Richard Sykes             538,665                             0.00866   a
Sir Roger Hurn                 10,539                             0.00017
Sir Peter Walters              31,398                             0.00050
Dr Jean-Pierre                105,694                             0.00170   b
Garnier
John Coombe                   164,203                             0.00264   c
Paul Allaire                   12,830                             0.00021   b
Michele Barzach                   812                             0.00001
Derek Bonham                    8,445                             0.00014
Sir Christopher Hogg            5,121                             0.00008
Peter Job                       2,003                             0.00003
John McArthur                   7,116                             0.00011   b
Donald McHenry                 12,080                             0.00019   b
Sir Ian Prosser                 2,315                             0.00004
Dr Ronaldo Schmitz              7,504                             0.00012   b
Dr Lucy Shapiro                 3,697                             0.00006   d
John Young                     19,650                             0.00032   d

Notes:

a.     Includes a non-beneficial interest in a trust which holds 36,612
Shares.

b.     Shares held as ADSs.

c.     Includes a non-beneficial interest in a trust which holds 20,397
Shares.

d.     Includes Shares and ADSs.



The following directors have interests in Shares arising from the grant of
options under Glaxo Wellcome plc share option plans:

Name of       Number of Shares     Exercise   Earliest date         Expiry
director      over which options   price      from which options    date
              are held             £          are exercisable

                                           

Sir                     92,236    16.10            27/12/2000    03/02/2003
Richard                                                                    
Sykes                  542,465    14.60            27/12/2000    24/08/2003
                                                                         
                    248 (SAYE)    13.27            27/12/2000    30/06/2001

                                                                         
John                   41,739     16.10            27/12/2000    03/08/2009
Coombe                                                                          
                      245,479     14.60            25/02/2003    24/02/2010
                                                                         
                   730 (SAYE)     13.27             1/12/2002    31/05/2003



The following director has an interest in ADSs arising from the grant of
options under SmithKline Beecham plc share option plans:

Name of       Number of ADSs      Exercise   Earliest date          Expiry
director      over which options  price      from which options      date
              are held            $          are exercisable 
                                   
                                            

          Dr         77,370      12.892091   24/11/1996           23/11/2003
 Jean-Pierre                                                               
     Garnier
                     28,582      12.870518   31/05/1997           30/05/2004

                    163,161      16.087083   20/07/1997           19/07/2004

                    231,052      14.530536   22/11/1997           21/11/2004

                     79,054      22.067443   15/11/1998           14/11/2005

                     68,411      28.159051   21/11/1999           20/11/2006

                     68,411      32.086995   24/03/2000           23/03/2007

                    225,324      40.536028   23/05/2000           12/11/2007

                    225,324      54.481547   23/05/2000           22/11/2008

                    341,400      61.353251   23/05/2000           14/03/2009

                    566,724      60.307557   23/05/2000           23/11/2009



The following directors have an interest in the Company's Shares arising from
Awards made under the Glaxo Wellcome Long Term Incentive Plan:

Name of director          Number of Shares       Award date        Release date

Sir Richard Sykes                   56,519       12/03/1998          31/12/2000

                                    39,969       24/03/1999          31/12/2000

                                    50,856       25/02/2000          31/12/2000

John Coombe                         25,120       12/03/1998          12/03/2001

                                    18,087       24/03/1999          24/03/2002

                                    23,013       25/02/2000          25/02/2003



The following director has an interest in the Company's ADSs arising from
Awards made under the SmithKline Beecham Mid-Term Incentive Plan:

Name of             Number of            Grant     Award        Deferred until
director            ADSs over            date      date                    (a) 
                    which interest                                              
                    is held

Dr Jean-Pierre      18,891         07/06/1996   15/03/1999        Deferred until

Garnier                                                           15/03/2002

                    18,891         21/11/1996   09/03/2000        Deferred until
                                                                  09/03/2003

                    18,891         24/03/1997  09/03/2000         Deferred until
                                                                  09/03/2003

                    18,891         13/11/1997  31/12/2000         -
                                                     
                    36,985         23/11/1998  31/12/2001         -
                                                    
                    36,985         24/11/1999  31/12/2002         -
                                                     

Note:


        (a)     After the grant has vested on the award date, the director may
        elect to defer receipt of the award for a three year period or until
        retirement.



S M Bicknell

Company Secretary

5th January 2001