Director Shareholding

GlaxoSmithKline PLC
5 January 2001



                             Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

4       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
January Trust ('the Trust'), transferred 10,278 Ordinary Shares in the Company
2001    to participants of the Senior Executive Long Term Incentive Plan.

        Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
        Trust ('the Trust'), also sold 30,203 Ordinary Shares in the Company at
        a price £17.36 per share.

The company was advised of the transactions on 5 January 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary



5 January 2001