Director Shareholding

GlaxoSmithKline PLC
20 April 2001

                             Directors' Interests

I give below details of changes in interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Directors or connected
persons, arising from the purchase of Ordinary shares on 17 April 2001 under a
Single Company ISA at a price of £18.70 per Ordinary Share:

Mr J D Coombe                                     5
Mrs G A Coombe(wife of Mr J D Coombe)             5
Mr P J D Job                                      8


The Company and directors were advised of this information on 19 April 2001.


S M Bicknell

Company Secretary



20 April 2001