Director Shareholding

GlaxoSmithKline PLC
3 January 2001



                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

2nd       Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome
January   Employee Trust ('the Trust'), sold 44,125 Ordinary Shares in the
2001      Company at £18.86 per share.


The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and it's subsidiaries.


S M Bicknell

Company Secretary


3rd January 2001