Director Shareholding

GlaxoSmithKline PLC
28 December 2000


                             Director's Interests


I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned directors:-


Sir     Exercised a nominal cost option on 27th December 2000 to acquire 56,276
Richard shares in the Company, which had vested under the Basic and Matching
B Sykes elements of the Glaxo Wellcome Annual Incentive Plan awarded in 1998
        and 1999. Sir Richard subsequently sold 22,557 of the shares so
        acquired at a price of £17.98 per share to pay the resultant tax
        liability and to meet the costs arising from the sale.

Mr J D  Exercised a nominal cost option on 27th December 2000 to acquire 21,528
Coombe  shares in the Company, which had vested under the Basic and Matching
        elements of the Glaxo Wellcome Annual Incentive Plan awarded in 1998
        and 1999. Mr Coombe subsequently sold 8,630 of the shares so acquired
        at a price of £17.98 per share to pay the resultant tax liability and
        to meet the costs arising from the sale.



The Company was advised of this transaction on 28th December 2000.





SM Bicknell

Company Secretary

28th December 2000