Director Shareholding

GlaxoSmithKline PLC
16 March 2001

                             Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

15    Abacus (GW) Trustees Limited, as trustee of The Glaxo Wellcome Employee
March Trust ('the Trust'), acquired 684,528 Ordinary shares in the Company at a
2001  price of £17.648093 per share. The Trust also sold 2,843 Ordinary shares
      in the Company at a price of £17.7025 per share.

The Company was advised of this transaction on 16 March 2001.

The Trust is a discretionary trust of which all employees or former employees
of Glaxo Wellcome plc and its subsidiaries are potential beneficiaries. Two of
the Company's directors, Sir Richard Sykes and John Coombe, as directors of
Glaxo Wellcome plc, are therefore interested in the shares held in the Trust
from time to time in the same way as other employees or former employees of
Glaxo Wellcome plc and its subsidiaries.


S M Bicknell

Company Secretary



16 March 2001