Director/PDMR Shareholding

GlaxoSmithKline PLC
26 March 2007

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares and Ordinary Share ADRs ("ADRs") of GlaxoSmithKline plc ("the Company").


22 March 2007     Abacus (GSK) Trustees Limited, as trustee of the
                  GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 10,923
                  Ordinary Shares in the Company at a price of £14.08 on behalf
                  of participants in the GlaxoSmithKline Performance Share Plan.

                  The GSK Trust transferred 40,892 Ordinary Shares of
                  GlaxoSmithKline plc to participants in the GlaxoSmithKline
                  Performance Share Plan.

                  The GSK Trust transferred 21,025 Ordinary Shares of
                  GlaxoSmithKline plc to participants in the SmithKline Beecham
                  Employee Share Option Plan 1991.


The Company was advised of these transactions on 23 March 2007.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

26 March 2007


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