Director/PDMR Shareholding

GlaxoSmithKline PLC 05 December 2005 Notification of Transactions of Directors, Persons Discharging Managerial Responsibility or Connected Persons I give below details of changes in the interests of Directors, Persons Discharging Managerial Responsibility or Connected Persons in the Ordinary Shares of GlaxoSmithKline plc. The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the Plan") notified GlaxoSmithKline plc on 5 December 2005, that as a result of a movement in the fund on 1 December 2005, the number of Ordinary Share ADRs held by the fund had changed from18,440,842 to 18,416,461 at an average price of $50.45 The Plan is a discretionary fund of which all employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially interested in the shares held in the fund from time to time in the same way as other employees or former employees of GlaxoSmithKline plc and its subsidiaries. This notification relates to a transaction notified in accordance with Disclosure Rule 3.1.4R (1) (b). S M Bicknell Company Secretary 5 December 2005 This information is provided by RNS The company news service from the London Stock Exchange

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