Director/PDMR Shareholding

GlaxoSmithKline PLC
01 August 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




   24 July 2006    The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                   Trust") notified the Company on 31 July 2006 that 433 Ordinary shares in the
                   Company had been sold on 24 July 2006 on behalf of participants in the
                   GlaxoSmithKline Bonus Investment Plan at a price of £14.87 per share.



   24 July 2006    The Trust notified the Company on 31 July 2006 that 9,505 Ordinary shares in
                   the Company had been sold on 24 July 2006 on behalf of participants in the
                   GlaxoSmithKline Bonus Investment Plan at a price of £14.89 per share.




   24 July 2006    The Trust notified the Company on 31 July 2006 that 69 Ordinary shares in the
                   Company had been sold on 24 July 2006 on behalf of participants in the
                   GlaxoSmithKline Bonus Investment Plan at a price of £15.06 per share.


   24 July 2006    The Trust notified the Company on 31 July 2006 that 619 Ordinary shares in the
                   Company had been transferred on 24 July 2006 from the Trust to a participant
                   in the GlaxoSmithKline Bonus Investment Plan.





The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell
Company Secretary



1 August 2006




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