Director/PDMR Shareholding

GlaxoSmithKline PLC
25 July 2006




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




   17 July 2006    The Administrators of the SmithKline Beecham Employee Benefit 
                   Trust ("the Trust") notified the Company on 24 July 2006 that 
                   453 Ordinary shares in the Company had been sold on 17 July 
                   2006 on behalf of participants in the GlaxoSmithKline Annual 
                   Investment Plan at a price of £14.73 per share.


   17 July 2006    The Trust notified the Company on 24 July 2006 that 645 
                   Ordinary shares in the Company had been transferred on 17 
                   July 2006 from the Trust to a participant in the 
                   GlaxoSmithKline Annual Investment Plan.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).




S M Bicknell
Company Secretary


25 July 2006




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