Director/PDMR Shareholding

GlaxoSmithKline PLC
19 July 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

   17 July 2006      Abacus (GSK) Trustees Limited, as trustee of the
                     GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 574
                     Ordinary Shares in the Company on behalf of participants in 
                     the GlaxoSmithKline Performance Share Plan at a price of 
                     £14.634 per share.

                     The GSK Trust transferred 1,871 Ordinary Shares in the 
                     Company to participants in the GlaxoSmithKline Performance 
                     Share Plan.


   18 July 2006      The GSK Trust transferred 8,135 Ordinary Shares in the 
                     Company to participants in the SmithKline Beecham Employee 
                     Share Option Plan 1991.


   19 July 2006      The GSK Trust sold 1,992 Ordinary Shares in the Company on
                     behalf of participants in the GlaxoSmithKline Share Value 
                     Plan at a price of £14.8525 per share.

                     The GSK Trust transferred 10,489 Ordinary Shares in the 
                     Company to participants in the GlaxoSmithKline Share Value 
                     Plan.


The Company was advised of these transactions on 19 July 2006.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

19 July 2006


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