Director/PDMR Shareholding

GlaxoSmithKline PLC
09 November 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the undermentioned persons arising
from the purchase of Ordinary Shares at a price of £15.30 per Ordinary Share on
9 November 2005 through the Company's ShareReward Plan ("the Plan") which the
under-mentioned persons entered on 5 October 2001:
                         
Mr J S Heslop            Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr R Bondy               Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mr A P Witty             Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)

Mrs J V Younger          Acquisition of 8 Ordinary Shares under the partnership 
                         element of the Plan (personal contribution)

                         Acquisition of 8 Ordinary Shares under the matching 
                         element of the Plan (Company contribution)


The above-mentioned persons and the Company were advised of this information on
9 November 2005.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary
9 November 2005


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