Director/PDMR Shareholding

GlaxoSmithKline PLC
01 March 2007



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the
Plan") notified GlaxoSmithKline plc on 28 February 2007, that as a result of a
movement in the fund on 22 February 2007, the number of Ordinary Share ADRs held
by the fund had changed from 16,282,764 to 16,249,606 at an average price of
$57.10



The Administrators of the Plan further notified GlaxoSmithKline plc on 28
February 2007, that as a result of a movement in the fund on 23 February 2007,
the number of Ordinary Share ADRs held by the fund had changed from 16,249,606
to 16,282,040 at an average price of $56.36





The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr M M Slaoui are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell
Company Secretary



1 March 2007






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