Director/PDMR Shareholding

GlaxoSmithKline PLC
20 February 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 20 February 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 16 February 2006 at a price of
$51.32 per share:-


Dr J P Garnier                                                         58
Dr W Calhoun                                                           10
Dr R Greig                                                             71
Mr D Phelan                                                            176
Dr D Pulman                                                            12
Mr D Stout                                                             27
Mr C Viehbacher                                                        3
Dr T Yamada                                                            20


This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell

Company Secretary

20 February 2006


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