Director/PDMR Shareholding

GlaxoSmithKline PLC
14 February 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 13 February 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 10 February 2006 at a price of
$51.52 per share:-

   Dr J P Garnier                                           90

   Dr W Calhoun                                             19

   Dr R Greig                                               21

   Mr D Phelan                                              24

   Dr D Pulman                                               7

   Mr D Stout                                               43

   Mr C Viehbacher                                           8

   Dr T Yamada                                              12


This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R (1) (a) and 3.1.4R (1) (b).


S M Bicknell

Company Secretary

14 February 2006




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