Director/PDMR Shareholding

GlaxoSmithKline PLC
08 November 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 8 November 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 2 November 2006 at a price of
$53.93 per share:-

Dr JP Garnier                                                          54
Dr MM Slaoui                                                           1
Dr F Calhoun                                                           11
Dr R Greig                                                             68
Mr D Phelan                                                            162
Dr D Pulman                                                            11
Mr D Stout                                                             27
Mr C Viehbacher                                                        4

Following a re-valuation of the cash element of the notional investment held
within the Plan, which is notionally held in GSK Ordinary Share ADRs, the
Administrators of the Plan notified GlaxoSmithKline plc and the under-mentioned
persons on 7 November 2006 of an increase in the notional allocation of Ordinary
Share ADRs on 3 November 2006 at a price of $53.30 per share:-

Dr MM Slaoui                                                           2
Dr R Greig                                                             3

These notifications relate to transactions notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

8 November 2006


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