Director/PDMR Shareholding

GlaxoSmithKline PLC
31 October 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in interests in the American Depositary Shares
(ADSs) of GlaxoSmithKline plc in respect of the under-mentioned Director:-


Dr J-P Garnier                Exercise of options on 30 October 2006 over 68,411 ADSs granted on 21
                              November 1996, which would have lapsed on 20 November 2006, under the
                              SmithKline Beecham Employee Share Option Plan 1991 at a price of $28.159 per
                              ADS. The sale of 45,500 ADSs on 30 October 2006 at an average price of
                              $53.12.

                              Following this transaction Dr Garnier's total shareholding in the Company is
                              529,769.32 ADSs, which includes 217,892 ADSs that have been earned but
                              deferred under the share programmes operated by the Company. At the price at
                              which the above options were exercised, Dr Garnier's holding is equivalent
                              to more than 16 times his annual basic salary.


The Company was advised of these transactions on 31 October 2006.

This notification is in accordance with Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary

31 October 2006


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