Director/PDMR Shareholding

GlaxoSmithKline PLC
04 December 2007



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of:
     
•    Directors and Persons Discharging Managerial Responsibility in the Ordinary 
     shares of GlaxoSmithKline plc in respect of the under mentioned persons
     arising from the sale of Ordinary shares at a price of £12.84 per Ordinary 
     share on 3 December 2007 to meet their tax liabilities following the 
     vesting of a Share Value Plan award:


                        No. of Award Shares   No. of Shares Sold   No. of Shares
                                                                   Retained

Dr M M Slaoui           3,350                 541                  2,809
Mr D Learmouth          3,160                 1,296                1,864

     
•    Persons Discharging Managerial Responsibility in the American Depositary 
     Shares (ADSs) of GlaxoSmithKline plc in respect of the under mentioned 
     person arising from the sale of ADSs at a price of $ 52.68 per ADS on 3 
     December 2007 to meet his  tax liabilities following the vesting of a Share
     Value Plan award:

                          No. of Award ADSs     No. of ADSs Sold     No. of ADSs
                                                                     Retained

Mr W Louv                 1,480                 500                  980


     
•    Dr M M Slaoui as a result from the sale of Ordinary shares at a price of                     
     £12.84 per Ordinary share on 3 December 2007 by his spouse, who is also 
     employed by the Company, to meet her tax liabilities following the vesting 
     of a Share Value Plan award:


                          No. of Award Shares   No. of Shares Sold   No. of Shares
                                                                     Retained

Mrs Claudine Bruck Slaoui 1,310                 417                  893



The Company, Directors, Persons Discharging Managerial Responsibility and
Connected Persons were advised of these transactions on 4 December 2007.

This notification relates to a transaction notified in accordance with
Disclosure and Transparency Rule 3.1.4R(1)(a).


S M Bicknell
Company Secretary

4 December 2007


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