Director/PDMR Shareholding

GlaxoSmithKline PLC
24 May 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




   16 May 2006             The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 24 May 2006 that 1,478 Ordinary shares in the
                           Company had been sold on 16 May 2006 on behalf of participants in the
                           GlaxoSmithKline Annual Investment Plan at a price of £15.23 per share.

   16 May 2006             The Trust notified the Company on 24 May 2006 that 1,777 Ordinary shares in
                           the Company had been transferred on 16 May 2006 from the Trust to a
                           participant in the GlaxoSmithKline Annual Ivestment Plan.

   17 May 2006             The Trust notified the Company on 24 May 2006 that 465 Ordinary shares in the
                           Company had been sold on 17 May 2006 on behalf of participants in the
                           GlaxoSmithKline Bonus Investment Plan at a price of £15.41 per share.

    17 May 2006            The Trust notified the Company on 24 May 2006 that 664 Ordinary shares in the
                           Company had been transferred on 17 May 2006 from the Trust to a participant in
                           the GlaxoSmithKline Bonus Investment Plan.

   18 May 2006             The Trust notified the Company on 24 May 2006 that 1,616 Ordinary shares in
                           the Company had been sold on 18 May 2006 on behalf of participants in the
                           GlaxoSmithKline Annual Investment Plan at a price of £15.05 per share.

   18 May 2006             The Trust notified the Company on 24 May 2006 that 2,252 Ordinary shares in
                           the Company had been transferred on 18 May 2006 from the Trust to a
                           participant in the GlaxoSmithKline Annual Investment Plan.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell
Company Secretary



24 May 2006




                      This information is provided by RNS
            The company news service from the London Stock Exchange