Director/PDMR Shareholding

GlaxoSmithKline PLC
10 May 2006


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                    
   2 May 2006       The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 
                    10 May 2006 that 10 Ordinary shares in the Company had 
                    been sold on 2 May 2006 on behalf of participants in the
                    SmithKline Beecham Unapproved Share Matching Plan at a 
                    price of £15.463 per share.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

10 May 2006



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