Director/PDMR Shareholding

GlaxoSmithKline PLC
10 October 2005




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.




04 October 2005            The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 10 October 2005 that 1,009 Ordinary shares in
                           the Company had been sold on 04 October 2005 on behalf of a participant in the
                           GlaxoSmithKline Annual Investment Plan at a price of £14.5836



                           The Trust also notified the Company on 10 October 2005 that 3,404 Ordinary
                           shares had been transferred from the Trust to a participant in the
                           GlaxoSmithKline Annual Investment Plan



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).





S M Bicknell

Company Secretary



10 October 2005




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