Director/PDMR Shareholding

GlaxoSmithKline PLC
10 October 2005


   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons





The Administrators of the GlaxoSmithKline Executive Supplemental Savings Plan
notified the Company and the under-mentioned persons on 10 October 2005 of
changes in their interests in Ordinary Share ADRs arising from an increase in
their interests under the Annual Investment Plan feature following the
re-investment of the dividend paid to shareholders on 06 October 2005 at a price
of $51.40 per share:-




Mr W Calhoun                       267.303

Dr J P Garnier                     259.331

Mr D Stout                         212.767

Dr T Yamada                        166.865

Mr J Ziegler                        68.543



This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).





S M Bicknell
Company Secretary



10 October 2005


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