Director/PDMR Shareholding

GlaxoSmithKline PLC
27 September 2006





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.


22 September 2006                Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), sold 2,386
                                 Ordinary Shares in the Company on behalf of participants in the
                                 GlaxoSmithKline Share Value Plan at a price of £14.22 per
                                 share.



22 September 2006                The GSK Trust transferred 9,562 Ordinary Shares to participants
                                 in the GlaxoSmithKline Share Value Plan.






The Company was advised of these transactions on 26 September 2006.


25 September 2006                Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                                 18,750 Ordinary Shares in the Company to participants in the
                                 SmithKline Beecham Employee Share Option Plan 1991.


25 September 2006                The GSK Trust transferred 5,095 Ordinary Shares in the Company
                                 to participants in the SmithKline Beecham Employee Share Option
                                 Plan 1991.





The Company was advised of these transactions on 27 September 2006.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr M M Slaoui
and Mr J S Heslop are therefore interested in the shares held in the GSK Trust
from time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).



S M Bicknell

Company Secretary



27 September 2006


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