Director/PDMR Shareholding

GlaxoSmithKline PLC
03 May 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                       
   25 April 2006    The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 
                    2 May 2006 that 93 Ordinary shares in the Company had 
                    been sold on 25 April 2006 on behalf of a participant 
                    in the SmithKline Beecham Unapproved Matching Plan at 
                    a price of £14.89.

The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

3 May 2006



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