Director/PDMR Shareholding

GlaxoSmithKline PLC
02 May 2006




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons



I give below details of changes in interests in the Ordinary shares of
GlaxoSmithKline plc in respect of the under-mentioned Person Discharging
Managerial Responsibility:-


Dr D Pulman      Exercise of options on 2 May 2006 over 7,215 Ordinary 
                 shares granted on 13 August 1997 under the Glaxo Wellcome 
                 International Share Option Scheme at a price of £12.75 per 
                 share.  Exercise of options on 2 May 2006 over 130,000
                 Ordinary shares granted on 3 December 2002 under the 
                 GlaxoSmithKline Share Option Plan at a price of £11.79 per 
                 share.

                 The sale of 137,215 shares on 2 May 2006 at a price of £15.47
                 per share.

                 The Company was advised of these transactions on 2 May 2006.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(a).



S M Bicknell
Company Secretary


2 May 2006


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