Director/PDMR Shareholding

GlaxoSmithKline PLC
28 April 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in interests in the Ordinary shares of
GlaxoSmithKline plc in respect of the under-mentioned Director:-



Mr J S Heslop                Exercise of options on 27 April 2006 over 54,000 Ordinary shares granted
                             on 3 December 2002 under the GlaxoSmithKline Share Option Plan at a price
                             of £11.79 per share.  The sale of 46,665 shares on 27 April 2006 at a
                             price of £15.41 to meet the resulting cost of exercise and tax.


                             Following this transaction Mr Heslop's total shareholding in the Company
                             has increased by 7,335 shares to 19,896.32 shares.


                             The Company was advised of this transaction on 27 April 2006.


This notification is in accordance with Disclosure Rule 3.1.4R(1)(b).


Mrs J Younger                Exercise of options on 27 April 2006 over 6,892 Ordinary shares granted
                             on 13 August 1997 under the Glaxo Wellcome International Share Option
                             Scheme at a price of £12.75 per share.  Exercise of options on 27 April
                             2006 over 45,000 Ordinary shares granted on 3 December 2002 under the
                             GlaxoSmithKline Share Option Plan at a price of £11.79 per share.



                             The sale of 53,298 shares on 27 April 2006 at an average price of £15.21.

                             The Company was advised of these transactions on 28 April 2006.


Mr R Bondy                   The transfer by gift of 2,880 Ordinary shares in GlaxoSmithKline plc on
                             27 April 2006.


                             The Company was advised of this transaction on 27 April 2006.


These notifications are in accordance with Disclosure Rule 3.1.4R(1)(a).


S M Bicknell
Company Secretary


28 April 2006






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