Director/PDMR Shareholding

GlaxoSmithKline PLC
30 January 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

23 January 2006            The Administrators of the SmithKline Beecham Employee 
                           Benefit Trust ("the Trust") notified the Company on 
                           30 January 2006 that 316 Ordinary shares in the 
                           Company had been sold on 23 January 2006 on behalf of 
                           a participant in the GlaxoSmithKline Annual 
                           Investment Plan at a price of £14.1928

                           The Trust also notified the Company on 30 January 
                           2006 that 294 Ordinary shares had been transferred 
                           from the Trust to a participant in the 
                           GlaxoSmithKline Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1 4R (1) (b).


S M Bicknell
Company Secretary

30 January 2006



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