Director/PDMR Shareholding

GlaxoSmithKline PLC
17 January 2006




   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan ("The Plan"), which is notionally held in
GSK Ordinary Share ADRs, the Administrators of the Plan notified GlaxoSmithKline
plc and the under-mentioned persons on 17 January 2006 of an increase in the
notional allocation of Ordinary Share ADRs on 13 January 2006 at a price of
$51.60 per share:-

Dr J P Garnier                                                         89
Dr W Calhoun                                                           18
Dr R Greig                                                             17
Mr D Phelan                                                            20
Dr D Pulman                                                            6
Mr D Stout                                                             42
Mr C Viehbacher                                                        8
Dr T Yamada                                                            11
Mr J Ziegler                                                           6

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary
17 January 2006


                      This information is provided by RNS
            The company news service from the London Stock Exchange