Director/PDMR Shareholding

GlaxoSmithKline PLC
11 January 2006



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

The Administrators of the SmithKline Beecham Mid-Term Incentive Plan notified
the Company and the under-mentioned persons on 10 January 2006 of an increase in
their interests in Ordinary Share ADRs at a price of $52.29 per ADR following
the re-investment of the dividend paid to shareholders on 5 January 2006.

Dr W Calhoun                                               116.964

Dr J P Garnier                                             1,144.357

Mr D Phelan                                                220.712

Dr D Stout                                                 88.219

Mr J Ziegler                                               71.210

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).


S M Bicknell
Company Secretary

11 January 2006


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