Director/PDMR Shareholding

GlaxoSmithKline PLC
10 January 2007



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

          The Administrators of the GlaxoSmithKline US Retirement 
          Savings Plan ("the Plan") notified GlaxoSmithKline plc 
          on 10 January 2007, that as a result of a movement in the 
          fund on 4 January 2007, the number of Ordinary Share ADRs 
          held by the fund had changed from 17,308,251 to 17,140,684 
          at an average price of $52.76

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr M M Slaoui are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary

10 January 2007


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